Proton Pump Inhibitor Use Ups Pneumonia Risk in Dementia

This article originally appeared here.
Share this content:
Proton Pump Inhibitor Use Ups Pneumonia Risk in Dementia
Proton Pump Inhibitor Use Ups Pneumonia Risk in Dementia

THURSDAY, March 30, 2017 (HealthDay News) -- For patients with dementia, proton pump inhibitor (PPI) use is associated with increased risk of pneumonia, according to a study published online March 21 in the Journal of the American Geriatrics Society.

Sai-Wai Ho, M.D., from the Chung Shan Medical University in Taichung, China, and colleagues conducted a retrospective cohort study involving 786 patients with dementia with new PPI usage and 786 matched patients with dementia without PPI usage.

The researchers found that patients with PPI usage had higher incidence of pneumonia (adjusted hazard ratio, 1.89). Independent risk factors for pneumonia included age, male gender, underlying cerebrovascular disease, chronic pulmonary disease, congestive heart failure, diabetes mellitus, and antipsychotic use (adjusted hazard ratios, 1.05, 1.57, 1.30, 1.39, 1.54, 1.54, and 1.29, respectively). Pneumonia risk was decreased with usage of cholinesterase inhibitors and histamine receptor-2 antagonists.

"PPI usage in dementia patients is associated with an 89 percent increased risk of pneumonia," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Hospitals Vary Widely in Moving Stroke Patients to Comfort Care

Hospitals Vary Widely in Moving Stroke Patients to ...

Doctors more apt to suggest it sooner for older, white, female, and uninsured patients

Peri-Op IV Acetaminophen May Reduce Post-Op Pain in Sinus Sx

Peri-Op IV Acetaminophen May Reduce Post-Op Pain in ...

Reduction in immediate postoperative pain after endoscopic sinus surgery, but results inconclusive

Location of Body Fat Can Indicate Obesity-Related Cancer Risk

Location of Body Fat Can Indicate Obesity-Related Cancer ...

Where fat is carried is as strong a predictor as BMI, researchers suggest

is free, fast, and customized just for you!

Already a member?

Sign In Now »