Gluten-Rich Foods Up Symptom Onset in Functional Dyspepsia

This article originally appeared here.
Share this content:
Gluten-Rich Foods Up Symptom Onset in Functional Dyspepsia
Gluten-Rich Foods Up Symptom Onset in Functional Dyspepsia

MONDAY, May 8, 2017 (HealthDay News) -- Gluten consumption impacts symptom onset in patients with functional dyspepsia (FD), according to a study published online April 28 in the Journal of Gastroenterology and Hepatology.

Lijun Du, from Zhejiang University in Hangzhou, China, and colleagues enrolled 101 patients newly diagnosed with FD and 31 asymptomatic controls in a prospective study. Self-reported questionnaires were used to evaluate specific FD symptoms and gluten consumption patterns. Immunohistochemistry was used to assess expression of tight junction protein (claudin-1) and presence of intraepithelial lymphocyte (IEL) infiltration in the bulb and second portion of the duodenum (D1 and D2, respectively).

The researchers found that in patients with FD versus controls, wheat bun consumption had higher frequency (P = 0.047) and increased average consumption (P = 0.01) scores. Early satiety correlated with increased wheat bun consumption frequency score among the patients with FD. Compared with controls, among patients with FD, claudin-1 expression was decreased in D1 (P = 0.003) and D2 (P < 0.001) on histologic evaluation, while duodenal IEL counts were increased in D1 and D2 (both P < 0.001). Among patients with FD there was a correlation between Helicobacter pylori infection and increased IELs in D1 (P = 0.001).

"Among patients with FD, gluten-rich food may lead to symptom onset, specifically early satiety," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Risk for Interval CRC Higher in Blacks Than Whites

Risk for Interval CRC Higher in Blacks Than ...

Differences most pronounced for cancer of the distal colon and the rectum

Even Small Amounts of Alcohol Can Affect Breast Cancer Risk

Even Small Amounts of Alcohol Can Affect Breast ...

Small glass of wine each day can up odds of both premenopausal and postmenopausal breast cancer

ATS: Angiotensin II Improves BP in Vasodilatory Shock

ATS: Angiotensin II Improves BP in Vasodilatory Shock

Angiotensin II effective for vasodilatory shock in patients not responding to conventional vasopressors

is free, fast, and customized just for you!

Already a member?

Sign In Now »