Bell's Palsy Tied to Quadrivalent Meningococcal Vaccine

Share this content:
Bell's Palsy Tied to Quadrivalent Meningococcal Vaccine
Bell's Palsy Tied to Quadrivalent Meningococcal Vaccine

WEDNESDAY, Dec. 28, 2016 (HealthDay News) -- Bell's palsy is the only prespecified adverse event associated with the MenACWY-CRM quadrivalent meningococcal conjugate vaccine, according to a study published online Dec. 26 in Pediatrics.

Hung-Fu Tseng, Ph.D., from the Southern California Permanente Medical Group in Pasadena, and colleagues evaluated data from 48,899 individuals, aged 11 to 21 years, receiving MenACWY-CRM, a quadrivalent meningococcal conjugate vaccine, between Sept. 30, 2011, and June 30, 2013. Electronic health records were used to identify 26 prespecified events of interest (EOIs) for up to one year after vaccination.

The researchers found that no cases were observed in the risk window for 14 of 26 EOIs. The relative incidence (RI) for Bell's palsy was statistically significant at 2.9 (95 percent confidence interval, 1.1 to 7.5). An increased risk for Bell's palsy in subjects receiving concomitant vaccines (RI, 5.0; 95 percent confidence interval, 1.4 to 17.8) was seen in stratified analyses, but no increased risk was seen for those without concomitant vaccine (RI, 1.1; 95 percent confidence interval, 0.2 to 5.5).

"The association needs further investigation as it could be due to chance, concomitant vaccination, or underlying medical history predisposing to Bell's palsy," the authors write.

Several authors disclosed financial ties to Novartis Vaccines and Diagnostics (now part of GlaxoSmithKline Vaccines), which funded the study.

Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Progress Made on Genetic Test for Anal Cancer

Progress Made on Genetic Test for Anal Cancer

But research is still in early stages

Four Separate Events Led to Zika's Introduction Into Florida

Four Separate Events Led to Zika's Introduction Into ...

Virus strains came from the Caribbean and Latin America, researchers say

New Health Care Act Could Result in 23 Million Losing Insurance

New Health Care Act Could Result in 23 ...

While premiums may lower over the long-term, many would face much higher out-of-pocket costs

is free, fast, and customized just for you!

Already a member?

Sign In Now »