Diagnostic Potential for Blood-Based NfL in Parkinson's Disease

This article originally appeared here.
Share this content:
Diagnostic Potential for Blood-Based NfL in Parkinson's Disease
Diagnostic Potential for Blood-Based NfL in Parkinson's Disease

WEDNESDAY, Feb. 8, 2017 (HealthDay News) -- Measuring blood neurofilament light chain (NfL) levels may help distinguish Parkinson's disease (PD) from atypical parkinsonian disorders (APD), according to a study published online Feb. 8 in Neurology.

For the study, Oskar Hansson, M.D., Ph.D., a researcher at Lund University in Sweden, and colleagues included 504 individuals from three independent prospective cohorts. Blood NfL levels were measured utilizing an ultrasensitive single molecule array method.

The team found strong correlations between blood and cerebrospinal fluid concentrations of NfL. Compared to patients with PD and healthy controls, blood NfL was increased in all APD groups. In one cohort, blood NfL was found to accurately distinguish PD from APD (area under the curve, 0.91), with similar results seen in the London and early disease cohorts (area under the curve, 0.85 and 0.81, respectively).

"Quantification of blood NfL concentration can be used to distinguish PD from APD," the authors write. "Blood-based NfL might consequently be included in the diagnostic workup of patients with parkinsonian symptoms in both primary care and specialized clinics."

Several authors disclosed financial ties to pharmaceutical and diagnostic companies, including UmanDiagnostics.

Abstract
Full Text
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Risk for Interval CRC Higher in Blacks Than Whites

Risk for Interval CRC Higher in Blacks Than ...

Differences most pronounced for cancer of the distal colon and the rectum

Even Small Amounts of Alcohol Can Affect Breast Cancer Risk

Even Small Amounts of Alcohol Can Affect Breast ...

Small glass of wine each day can up odds of both premenopausal and postmenopausal breast cancer

ATS: Angiotensin II Improves BP in Vasodilatory Shock

ATS: Angiotensin II Improves BP in Vasodilatory Shock

Angiotensin II effective for vasodilatory shock in patients not responding to conventional vasopressors

is free, fast, and customized just for you!

Already a member?

Sign In Now »