Novel Oral Budesonide Prep Treats Eosinophilic Esophagitis

This article originally appeared here.
Share this content:
Novel Oral Budesonide Prep Treats Eosinophilic Esophagitis
Novel Oral Budesonide Prep Treats Eosinophilic Esophagitis

TUESDAY, March 28, 2017 (HealthDay News) -- Budesonide oral suspension (BOS) is associated with improvement in symptomatic, endoscopic, and histologic parameters in adolescent and young adult patients with eosinophilic esophagitis (EoE), according to a study published in the March issue of Gastroenterology.

Evan S. Dellon, M.D., M.P.H., from the University of North Carolina at Chapel Hill, and colleagues conducted a trial involving 93 EoE patients aged 11 to 40 years with dysphagia and active esophageal eosinophilia who were randomly allocated to receive BOS or placebo twice daily.

The mean Dysphagia Symptom Questionnaire (DSQ) scores were 29.3 and 29.0 at baseline in the BOS and placebo groups, respectively, and mean peak eosinophil counts were 156 and 130 per high-power field (hpf), respectively. The researchers found that DSQ scores were 15.0 and 21.5 in the BOS and placebo groups, respectively, after treatment, and the corresponding mean peak eosinophil counts were 39 and 113 per hpf (all P < 0.05). For BOS versus placebo there were significant changes in DSQ score (−14.3 versus −7.5; P = 0.0096), histologic response rates (39 versus 3 percent; P < 0.0001), and endoscopic severity score (−3.8 versus 0.4; P < 0.0001). Similar adverse events were seen between the groups.

"Treatment with BOS was well tolerated in adolescent and young adult patients with EoE and resulted in improvement in symptomatic, endoscopic, and histologic parameters using validated outcome instruments," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Meritage Pharma, which funded the study.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Risk for Interval CRC Higher in Blacks Than Whites

Risk for Interval CRC Higher in Blacks Than ...

Differences most pronounced for cancer of the distal colon and the rectum

Even Small Amounts of Alcohol Can Affect Breast Cancer Risk

Even Small Amounts of Alcohol Can Affect Breast ...

Small glass of wine each day can up odds of both premenopausal and postmenopausal breast cancer

ATS: Angiotensin II Improves BP in Vasodilatory Shock

ATS: Angiotensin II Improves BP in Vasodilatory Shock

Angiotensin II effective for vasodilatory shock in patients not responding to conventional vasopressors

is free, fast, and customized just for you!

Already a member?

Sign In Now »