Vildagliptin, Metformin Have Different Effects on BP in T2DM

Share this content:
Vildagliptin, Metformin Have Different Effects on BP in T2DM
Vildagliptin, Metformin Have Different Effects on BP in T2DM

WEDNESDAY, March 8, 2017 (HealthDay News) -- For patients with type 2 diabetes, vildagliptin lowers blood pressure (BP) and elevates heart rate (HR), while metformin increases HR with no effect on BP during intraduodenal (ID) glucose infusion, according to a study published online March 3 in Diabetes Care.

Tongzhi Wu, M.D., Ph.D., from the University of Adelaide in Australia, and colleagues examined the effects of vildagliptin and metformin on BP and HR responses to ID glucose in patients with diet-controlled type 2 diabetes. Study A compared vildagliptin and placebo given 60 minutes before a 120-minute ID glucose infusion (at 2 or 4 kcal/min [ID2 and ID4]) in 16 patients, while study B compared metformin and placebo given 30 minutes before ID2 over 120 minutes in nine patients.

The researchers found that after vildagliptin versus placebo, systolic and diastolic BP were lower (P = 0.002 and P < 0.001) and HR was higher (P = 0.005); there was no correlation between vildagliptin and the rate of glucose infusion. HR was increased after metformin versus placebo (P < 0.001), with no difference in systolic or diastolic BP.

"Vildagliptin reduces BP and increases HR, whereas metformin increases HR without affecting BP during ID glucose infusion in type 2 diabetes," the authors write. "These distinct cardiovascular profiles during enteral nutrient exposure may have implications for postprandial hypotension."

Study A was supported by Novartis, which supplied the vildagliptin and matching placebo tablets. Study B was funded by Merck Sharp & Dohme, which arranged the supply of metformin and placebo.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Risk for Interval CRC Higher in Blacks Than Whites

Risk for Interval CRC Higher in Blacks Than ...

Differences most pronounced for cancer of the distal colon and the rectum

Even Small Amounts of Alcohol Can Affect Breast Cancer Risk

Even Small Amounts of Alcohol Can Affect Breast ...

Small glass of wine each day can up odds of both premenopausal and postmenopausal breast cancer

ATS: Angiotensin II Improves BP in Vasodilatory Shock

ATS: Angiotensin II Improves BP in Vasodilatory Shock

Angiotensin II effective for vasodilatory shock in patients not responding to conventional vasopressors

is free, fast, and customized just for you!

Already a member?

Sign In Now »