Exposure to Phthalates, BPA May Impact Total 25(OH)D in Adults

This article originally appeared here.
Share this content:
Exposure to Phthalates, BPA May Impact Total 25(OH)D in Adults
Exposure to Phthalates, BPA May Impact Total 25(OH)D in Adults

FRIDAY, Sept. 23, 2016 (HealthDay News) -- Exposure to phthalates and bisphenol A (BPA) may impact circulating levels of total 25-hydroxyvitamin D (25[OH]D), according to a study published online Sept. 20 in the Journal of Clinical Endocrinology & Metabolism.

Lauren E. Johns, M.P.H.S., from the University of Michigan School of Public Health in Ann Arbor, and colleagues examined the correlation between urinary concentrations of 11 phthalate metabolites and BPA and serum 25(OH)D in a cross-sectional study. Data were obtained from the U.S. National Health and Nutrition Examination Survey 2005 to 2010 for adults (aged ≥20 years).

The researchers observed a consistent inverse association for metabolites of di(2-ethylhexyl) phthalate (DEHP) with total 25(OH)D in the study cohort and in gender-stratified models. There was a significant inverse correlation for the molar sum of DEHP metabolites (ΣDEHP), while an increase in ΣDEHP correlated with a 1.90 percent decrease in total 25(OH)D. There was a positive correlation for monoethyl phthalate. A statistically significant inverse association was found for BPA in women, but not men. An increase in interquartile range in urinary BPA correlated with a 3.71 percent decrease in total 25(OH)D in women.

"Our results provide suggestive evidence that environmental exposure to phthalates and BPA may alter circulating levels of total 25(OH)D in adults," the authors write. "Future human and animal studies are required to resolve the direction, temporality, and impact of these relationships."

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Alzheimer's Mortality Up 55 Percent From 1999 to 2014

CDC: Alzheimer's Mortality Up 55 Percent From 1999 ...

More patients also dying at home, with the caregiving burden often falling on loved ones

Targeting ANGPTL3 Can Significantly Lower Cholesterol

Targeting <i>ANGPTL3</i> Can Significantly Lower Cholesterol

Two trials show promise for non-statin approach to cardiovascular disease prevention

Factors Raise Risk of Pregnancy-Related Stroke in Preeclampsia

Factors Raise Risk of Pregnancy-Related Stroke in Preeclampsia

Infections, clotting disorders, chronic hypertension all found to increase risk

is free, fast, and customized just for you!

Already a member?

Sign In Now »