Lower Citrulline Values With Metformin Treatment in T2DM

Share this content:
Lower Citrulline Values With Metformin Treatment in T2DM
Lower Citrulline Values With Metformin Treatment in T2DM

THURSDAY, Sept. 15, 2016 (HealthDay News) -- For patients with type 2 diabetes mellitus (T2DM), metformin treatment is associated with lower citrulline values, according to a study published online Sept. 12 in Diabetes.

Jonathan Adam, from Helmholtz Zentrum München in Neuherberg, Germany, and colleagues used a non-targeted metabolomics approach to examine metformin's pleiotropic effect. A total of 353 metabolites were analyzed in fasting serum samples of the population-based human Cooperative Health Research in the Region of Augsburg (KORA) F4 cohort. Patients with T2DM treated with metformin (mt-T2D; 74 patients) were compared with those without antidiabetic medication (ndt-T2D; 115 patients). The initial findings were confirmed in longitudinal samples of 683 KORA participants. Findings from the human study were corroborated using murine plasma, liver, skeletal muscle, and epididymal adipose tissue samples for metformin treated-db/db mice.

The researchers found that when comparing mt-T2D with ndt-T2D, citrulline showed lower values, and an unknown metabolite X-21365 showed higher relative concentrations in human serum. In patients who started metformin treatment, citrulline was confirmed to be significantly decreased at seven years' follow-up. Significantly lower citrulline values were validated in plasma, skeletal muscle, and adipose tissue of metformin-treated mice, but not in their liver.

"In summary, we observed that serum values of citrulline were reduced under metformin treatment in human patients with T2DM and, in a translational approach, also in plasma, skeletal muscle, and epididymal adipose tissue of diabetic mice," the authors write.

Several authors disclosed financial ties to the biopharmaceutical industry.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

ACOG: Shared Decision-Making Key to Breast Cancer Screening

ACOG: Shared Decision-Making Key to Breast Cancer Screening

Critically important for patient's value, preferences be factored into process, ACOG leader says

Three Lifestyle Interventions May Slow Cognitive Decline

Three Lifestyle Interventions May Slow Cognitive Decline

Cognitive training, management of hypertension, increased physical activity all help delay decline

CDC: Zika Can Be Found in Placental, Fetal Tissue at Birth

CDC: Zika Can Be Found in Placental, Fetal ...

Of 546 live births with possible maternal Zika virus, 11 percent proved positive

is free, fast, and customized just for you!

Already a member?

Sign In Now »