Depressive Disorders Up With Antimuscarinics for OAB

This article originally appeared here.
Share this content:
Depressive Disorders Up With Antimuscarinics for OAB
Depressive Disorders Up With Antimuscarinics for OAB

WEDNESDAY, April 12, 2017 (HealthDay News) -- Women with overactive bladder (OAB) syndrome treated with antimuscarinics have increased subsequent risk of depressive disorder, according to a study published online April 5 in the Journal of Clinical Pharmacology.

Shiu-Dong Chung, Ph.D., M.D., from the Far Eastern Memorial Hospital in Taiwan, and colleagues conducted a retrospective cohort study to examine the correlation between antimuscarinic use and subsequent risk of depressive disorder. Data were obtained from the Taiwan Longitudinal Health Insurance Database 2005 for 1,952 women with OAB who received antimuscarinics and 9,760 who did not receive antimuscarinics. The women were followed for three years from the index date.

The researchers found that the adjusted hazard ratio for depressive disorder was 1.38 (95 percent confidence interval, 1.15 to 1.64) for women with OAB who received antimuscarinics versus those who did not receive antimuscarinics. For women with OAB aged 18 to 39, 40 to 59, and ≥60 years who received antimuscarinics, the adjusted hazard ratios for subsequent depressive disorder were 1.83 (95 percent confidence interval, 1.27 to 2.64), 1.36 (95 percent confidence interval, 1.03 to 1.81), and 1.16 (95 percent confidence interval, 0.86 to 1.56), respectively.

"Clinicians should be alert to the relationship between antimuscarinics usage and depressive disorder in OAB women and provide appropriate instructions for these patients," the authors write.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Risk for Interval CRC Higher in Blacks Than Whites

Risk for Interval CRC Higher in Blacks Than ...

Differences most pronounced for cancer of the distal colon and the rectum

Even Small Amounts of Alcohol Can Affect Breast Cancer Risk

Even Small Amounts of Alcohol Can Affect Breast ...

Small glass of wine each day can up odds of both premenopausal and postmenopausal breast cancer

ATS: Angiotensin II Improves BP in Vasodilatory Shock

ATS: Angiotensin II Improves BP in Vasodilatory Shock

Angiotensin II effective for vasodilatory shock in patients not responding to conventional vasopressors

is free, fast, and customized just for you!

Already a member?

Sign In Now »