Postbiotic Could Lower Glucose, Inflammation in Obesity

Share this content:
Postbiotic Could Lower Glucose, Inflammation in Obesity
Postbiotic Could Lower Glucose, Inflammation in Obesity

WEDNESDAY, April 26, 2017 (HealthDay News) -- The bacterial cell wall-derived muramyl dipeptide (MDP) postbiotic lowers adipose inflammation and reduces glucose intolerance in obese mice, according to an experimental study published online April 20 in Cell Metabolism.

Joseph F. Cavallari, from McMaster University in Ontario, Canada, and colleagues examined the role of MDP, which is an insulin-sensitizing postbiotic that requires NOD2 in obese mice.

The researchers found that in obese mice, injection of MDP lowered adipose inflammation and reduced glucose intolerance without resulting in weight loss or changing the microbiome composition. During obesity and low-level endotoxemia, MDP correlated with a reduction in hepatic insulin resistance. Glucose tolerance was worsened with NOD1-activating muropeptides. For different types of peptidoglycan, IRF4 distinguished opposing glycemic responses; IRF4 was required for MDP/NOD2-induced insulin sensitization and lower metabolic tissue inflammation during obesity and endotoxemia. For exacerbated glucose intolerance via NOD1, IRF4 was dispensable. In obese mice, the MDP-based orphan drug mifamurtide was an insulin sensitizer at clinically relevant doses.

"Our results highlight that discovery and repurposing of microbial-derived natural products should be considered in obesity-related metabolic disease and that postbiotics may represent an underutilized avenue of potential drug alternatives," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Risk for Interval CRC Higher in Blacks Than Whites

Risk for Interval CRC Higher in Blacks Than ...

Differences most pronounced for cancer of the distal colon and the rectum

Even Small Amounts of Alcohol Can Affect Breast Cancer Risk

Even Small Amounts of Alcohol Can Affect Breast ...

Small glass of wine each day can up odds of both premenopausal and postmenopausal breast cancer

ATS: Angiotensin II Improves BP in Vasodilatory Shock

ATS: Angiotensin II Improves BP in Vasodilatory Shock

Angiotensin II effective for vasodilatory shock in patients not responding to conventional vasopressors

is free, fast, and customized just for you!

Already a member?

Sign In Now »