Eight Immune Genes Identified As Playing a Role in Glioblastoma

This article originally appeared here.
Share this content:
Eight Immune Genes Identified As Playing a Role in Glioblastoma
Eight Immune Genes Identified As Playing a Role in Glioblastoma

THURSDAY, May 26, 2016 (HealthDay News) -- Researchers have identified immune genes that may affect mortality in patients with glioblastoma multiforme, according to a study published online May 25 in Neurology.

Anhua Wu, M.D., Ph.D., of the First Hospital of China Medical University in Shenyang, and colleagues looked at tissue samples from 127 patients with glioblastoma. They also looked at tissue samples from 170 patients with lower grade gliomas.

The researchers discovered eight immune genes that play a role in glioblastoma (FOXO3, IL6, IL10, ZBTB16, CCL18, AIMP1, FCGR2B, and MMP9). Three of the genes protect against glioblastoma. Five of the genes increase the risk of early death in patients with glioblastoma. The team then looked at more than 500 samples from another group of patients with glioblastoma. These samples revealed the same eight genes, the study authors noted.

Rifaat Bashir, M.D., a retired neurologist in Reston, Va., wrote an editorial accompanying the study. "The looming question in brain cancer research today is whether the launch of immunotherapy will help control an uncontrollable disease," Bashir said in a journal news release. "While this study does not answer this question, it brings us one step closer to believing that one day we will be able to exploit the immune system to better treat glioblastoma."

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Progress Made on Genetic Test for Anal Cancer

Progress Made on Genetic Test for Anal Cancer

But research is still in early stages

Four Separate Events Led to Zika's Introduction Into Florida

Four Separate Events Led to Zika's Introduction Into ...

Virus strains came from the Caribbean and Latin America, researchers say

New Health Care Act Could Result in 23 Million Losing Insurance

New Health Care Act Could Result in 23 ...

While premiums may lower over the long-term, many would face much higher out-of-pocket costs

is free, fast, and customized just for you!

Already a member?

Sign In Now »