New Way Bacteria Can Trigger Inflammation in Acne Identified

Share this content:
New Way Bacteria Can Trigger Inflammation in Acne Identified
New Way Bacteria Can Trigger Inflammation in Acne Identified

MONDAY, Oct. 31, 2016 (HealthDay News) -- In research published online Oct. 28 in Science Immunology, scientists say they've discovered a previously unrecognized way in which bacteria trigger inflammation in the skin.

Richard Gallo, M.D., Ph.D., interim chair of dermatology at the University of California, San Diego, and colleagues focused on the Propionibacterium acnes bacteria.

In lab experiments, the researchers found that under certain conditions, P. acnes will secrete short-chain fatty acids (SCFAs) that inhibit histone deacetylase activity in keratinocytes. That, in turn, boosts the cells' inflammatory reactions. The team also found that administration of SCFAs under the skin blocked inflammation, suggesting that P. acnes SCFAs have opposing effects on different cell types.

"Our results demonstrate that metabolites produced by members of the skin microbiome are a critical factor that turns off epithelial tolerance to resident bacteria," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Risk for Interval CRC Higher in Blacks Than Whites

Risk for Interval CRC Higher in Blacks Than ...

Differences most pronounced for cancer of the distal colon and the rectum

Even Small Amounts of Alcohol Can Affect Breast Cancer Risk

Even Small Amounts of Alcohol Can Affect Breast ...

Small glass of wine each day can up odds of both premenopausal and postmenopausal breast cancer

ATS: Angiotensin II Improves BP in Vasodilatory Shock

ATS: Angiotensin II Improves BP in Vasodilatory Shock

Angiotensin II effective for vasodilatory shock in patients not responding to conventional vasopressors

is free, fast, and customized just for you!

Already a member?

Sign In Now »