High-Dose Steroid No Benefit to Platelets in Preeclampsia

Share this content:
High-Dose Steroid No Benefit to Platelets in Preeclampsia
High-Dose Steroid No Benefit to Platelets in Preeclampsia

FRIDAY, June 10, 2016 (HealthDay News) -- High-dose methylprednisolone does not prevent platelet decline in women with preeclampsia and platelet counts below 150 × 109/L, according to a study published in the July issue of Obstetrics & Gynecology.

Olivier Pourrat, M.D., Ph.D., from the Centre d'Investigation Clinique in Poitiers, France, and colleagues conducted a randomized trial of 180 mg methylprednisolone or placebo administered in divided doses over 36 hours to women admitted for preeclampsia and platelet counts below 150 × 109/L. Thirty-six women were randomized to receive methylprednisolone and 34 to receive placebo.

The researchers found that 83 percent of the active group and 85 percent of the placebo group had platelet counts above 100 × 109/L at 36 hours after the first dose of study medication (relative risk, 0.98; 95 percent confidence interval, 0.80 to 1.20). One woman allocated to methylprednisolone had hyperglycemia, which was the only potentially study-related adverse event.

"In women with preeclampsia and platelet counts under 150 × 109/L, methylprednisolone was not effective in maintaining platelet counts above 100 × 109/L," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Risk for Interval CRC Higher in Blacks Than Whites

Risk for Interval CRC Higher in Blacks Than ...

Differences most pronounced for cancer of the distal colon and the rectum

Even Small Amounts of Alcohol Can Affect Breast Cancer Risk

Even Small Amounts of Alcohol Can Affect Breast ...

Small glass of wine each day can up odds of both premenopausal and postmenopausal breast cancer

ATS: Angiotensin II Improves BP in Vasodilatory Shock

ATS: Angiotensin II Improves BP in Vasodilatory Shock

Angiotensin II effective for vasodilatory shock in patients not responding to conventional vasopressors

is free, fast, and customized just for you!

Already a member?

Sign In Now »