ASCO Updates Guideline for SNB in Early-Stage Breast Cancer

Share this content:
ASCO Updates Guideline for SNB in Early-Stage Breast Cancer
ASCO Updates Guideline for SNB in Early-Stage Breast Cancer

THURSDAY, Dec. 22, 2016 (HealthDay News) -- Recommendations for use of sentinel node biopsy (SNB) in early-stage breast cancer are unchanged from 2014, according to a clinical practice guideline update published online Dec. 12 in the Journal of Clinical Oncology.

Gary H. Lyman, M.D., M.P.H., from the Fred Hutchinson Cancer Research Center in Seattle, and colleagues conducted a systematic literature review to provide current recommendations on the use of SNB for patients with early-stage breast cancer.

The researchers found that none of the eight publications identified and reviewed prompted a change in the 2014 recommendations. Axillary lymph node dissection (ALND) is not recommended for women without sentinel lymph node (SLN) metastases. In most cases, women with one to two metastatic SLNs who intend to undergo breast-conserving surgery with whole-breast radiotherapy should not undergo ALND. ALND should be offered to women with SLN metastases who will undergo mastectomy. These recommendations are based on data from randomized controlled trials. SNB may be offered to women with operable breast cancer and multicentric tumors, with ductal carcinoma in situ, who will undergo mastectomy, who previously underwent breast and/or axillary surgery, or who received preoperative/neoadjuvant systemic therapy.

"Women who have large or locally-advanced invasive breast cancer (tumor size T3/T4), inflammatory breast cancer, or ductal carcinoma in situ (when breast-conserving surgery is planned), or are pregnant should not undergo SNB," the authors write.

Several authors disclosed financial ties to the biopharmaceutical industry.

Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

ATS: Cancer-Related Suicide Risk Highest for Lung Cancer Patients

ATS: Cancer-Related Suicide Risk Highest for Lung Cancer ...

Odds up four-fold compared to people in the general population

Mortality Rates Found Lower at Major Teaching Hospitals

Mortality Rates Found Lower at Major Teaching Hospitals

Researchers assessed 30-day survival for older patients

Opioid Use Before TKA May Lead to Worse Pain After Surgery

Opioid Use Before TKA May Lead to Worse ...

Researchers suggest limiting opioid prescriptions might optimize benefits of TKA

is free, fast, and customized just for you!

Already a member?

Sign In Now »