Novel Index Predicts Survival After Chemo in Pancreatic Cancer

This article originally appeared here.
Share this content:
Novel Index Predicts Survival After Chemo in Pancreatic Cancer
Novel Index Predicts Survival After Chemo in Pancreatic Cancer

MONDAY, May 16, 2016 (HealthDay News) -- For patients with advanced pancreatic cancer receiving chemotherapy, the systemic inflammation response index (SIRI), based on peripheral neutrophil, monocyte, and lymphocyte counts, can predict survival, according to a study published online May 6 in Cancer.

Qi Qi, M.D., from the Fudan University Shanghai Cancer Center, and colleagues developed the SIRI in a training set of 177 patients with advanced pancreatic cancer who had received palliative chemotherapy. The predictive ability was validated in two independent cohorts with 397 patients.

The researchers found that in the training cohort, patients with a SIRI ≥1.8 had a shorter time to progression (TTP) than patients with a SIRI <1.8 (hazard ratio, 2.348; P = 0.003); they also had shorter overall survival (OS) (hazard ratio, 2.789; P < 0.001). The two independent validation cohorts had comparable TTP and OS findings. SIRI was confirmed as an independent prognostic factor for TTP and OS in multivariate analysis. An increase in SIRI at week eight, compared with no change, correlated with poor TTP and OS; in contrast, a decrease in SIRI correlated with improved outcomes.

"The SIRI can be used to predict the survival of patients with pancreatic adenocarcinomas who receive chemotherapy, potentially allowing clinicians to improve treatment outcomes by identifying candidates for aggressive therapy," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

SAMHSA: Youth Binge Drinking Rates Down in the United States

SAMHSA: Youth Binge Drinking Rates Down in the ...

But one in seven still consumed excess alcohol at least once in past month, study finds

Carpal Tunnel Up With Increased Electronic Device Use

Carpal Tunnel Up With Increased Electronic Device Use

Especially for those who spend more than five hours a day on their devices, researchers say

Guided Approach to Exercise May Help Chronic Fatigue Patients

Guided Approach to Exercise May Help Chronic Fatigue ...

Guided self-help approach to graded exercise program safe, reduces fatigue

is free, fast, and customized just for you!

Already a member?

Sign In Now »