Gluten Challenge Rarely Confirms Diagnosis of Gluten Sensitivity

This article originally appeared here.
Share this content:
Gluten Challenge Rarely Confirms Diagnosis of Gluten Sensitivity
Gluten Challenge Rarely Confirms Diagnosis of Gluten Sensitivity

WEDNESDAY, March 8, 2017 (HealthDay News) -- For patients diagnosed with nonceliac gluten sensitivity (NCGS), double-blind, placebo-controlled gluten challenge rarely confirms diagnosis, according to research published in the March issue of Clinical Gastroenterology and Hepatology.

Javier Molina-Infante, M.D., Ph.D., from the Hospital Universitario San Pedro de Alcantara in Spain, and Antonio Carroccio, M.D., from the University of Palermo in Italy, analyzed data from 10 double-blind placebo-controlled gluten-challenge trials involving 1,312 adults to determine the accuracy of this approach for confirming a diagnosis of NCGS. The studies varied in the duration of the challenge, daily doses for the challenge, and composition of the placebo.

The researchers found that in most studies the gluten challenge significantly increased symptom scores compared with placebo. However, gluten-specific symptoms were seen in only 16 percent of the 231 NCGS patients, while 40 percent showed a nocebo response (similar or increased symptoms in response to placebo).

"These findings reveal heterogeneity and potential methodology flaws among studies of gluten challenge, cast doubt on gluten as the culprit food component in most patients with presumptive NCGS, and highlight the importance of the nocebo effect in these types of studies," the authors write.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

SAMHSA: Youth Binge Drinking Rates Down in the United States

SAMHSA: Youth Binge Drinking Rates Down in the ...

But one in seven still consumed excess alcohol at least once in past month, study finds

Carpal Tunnel Up With Increased Electronic Device Use

Carpal Tunnel Up With Increased Electronic Device Use

Especially for those who spend more than five hours a day on their devices, researchers say

Guided Approach to Exercise May Help Chronic Fatigue Patients

Guided Approach to Exercise May Help Chronic Fatigue ...

Guided self-help approach to graded exercise program safe, reduces fatigue

is free, fast, and customized just for you!

Already a member?

Sign In Now »