Research for Post-Craniotomy Analgesia Uneven in Quality

Share this content:
Research for Post-Craniotomy Analgesia Uneven in Quality
Research for Post-Craniotomy Analgesia Uneven in Quality

FRIDAY, Dec. 23, 2016 (HealthDay News) -- Studies reporting pharmacological and adjuvant analgesic modalities for post-craniotomy pain control have significant divergence in their research methods, according to a review published online Dec. 20 in Pain Practice.

Georgia G. Tsaousi, M.D., Ph.D., from Aristotle University of Thessaloniki in Greece, and colleagues conducted a systematic review of the literature to report current clinical evidence relating to pharmacological and adjuvant analgesic modalities for post-craniotomy pain control. Nineteen randomized controlled trials (RCTs) with 1,805 patients were included.

The researchers found that quality of research methods was moderate to good for most of the studies. Fourteen RCTs assessed systemic pharmacological intervention. Superior pain relief was provided by opioids (five RCTs), with no significant side effects, but the study quality was low. Adequate craniotomy pain control was presented by diclofenac (three RCTs), without adverse effects, but there was no support for parecoxib. Adequate transitional analgesia was provided by dexmedetomidine (three RCTs), but further research is needed. Very limited data were available on the analgesic efficacy of gabapentin, pregabalin, and intravenous lidocaine (one RCT each). In the early postoperative period, scalp infiltration/block provided adequate analgesia (three RCTs), while more studies are needed to verify the analgesic benefit from nonpharmacological interventions (two RCTs).

"No definite recommendations can be made based on this systematic review of pharmacological interventions following craniotomy due to significant divergence in the methodology of available studies," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Progress Made on Genetic Test for Anal Cancer

Progress Made on Genetic Test for Anal Cancer

But research is still in early stages

Four Separate Events Led to Zika's Introduction Into Florida

Four Separate Events Led to Zika's Introduction Into ...

Virus strains came from the Caribbean and Latin America, researchers say

New Health Care Act Could Result in 23 Million Losing Insurance

New Health Care Act Could Result in 23 ...

While premiums may lower over the long-term, many would face much higher out-of-pocket costs

is free, fast, and customized just for you!

Already a member?

Sign In Now »