Rate of CVD Mortality, MI, Stroke Down for Patients on Semaglutide

This article originally appeared here.
Share this content:
Rate of CVD Mortality, MI, Stroke Down for Patients on Semaglutide
Rate of CVD Mortality, MI, Stroke Down for Patients on Semaglutide

FRIDAY, Sept. 16, 2016 (HealthDay News) -- Semaglutide is noninferior to placebo for patients with type 2 diabetes at high cardiovascular risk, according to a study published online Sept. 16 in the New England Journal of Medicine. The research was published to coincide with the annual meeting of the European Association for the Study of Diabetes, held from Sept. 12 to 16 in Munich.

Steven P. Marso, M.D., from Research Medical Center in Kansas City, Mo., and colleagues randomized 3,297 patients with type 2 diabetes to receive once-weekly semaglutide or placebo for 104 weeks. At baseline, 83.0 percent of the patients had established cardiovascular disease, chronic kidney disease, or both.

The researchers found that the primary outcome (composite of first occurrence of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke) occurred in 6.6 percent of patients in the semaglutide group and in 8.9 percent of the placebo group (hazard ratio, 0.74; 95 percent confidence interval, 0.58 to 0.95; P < 0.001 for noninferiority). Non-fatal myocardial infarction occurred in 2.9 and 3.9 percent of those receiving semaglutide and placebo, respectively (hazard ratio, 0.74; 95 percent confidence interval, 0.51 to 1.08), while nonfatal stroke occurred in 1.6 and 2.7 percent, respectively (hazard ratio, 0.61; 95 percent confidence interval, 0.38 to 0.99). The groups had similar rates of death from cardiovascular causes.

"The rate of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke was significantly lower among patients receiving semaglutide than among those receiving placebo, an outcome that confirmed the noninferiority of semaglutide," the authors write.

Several authors disclosed financial ties to Novo Nordisk, which manufactures semaglutide and funded the study.

Abstract
Full Text
More Information

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Occupation Tied to Risk of Vitamin D Deficiency

Occupation Tied to Risk of Vitamin D Deficiency

Findings may help target health promotion and preventive efforts, researchers say

Patient-Controlled Analgesia Reduces Pain at Higher Cost

Patient-Controlled Analgesia Reduces Pain at Higher Cost

Costs were higher among patients with pain from traumatic injuries, non-traumatic abdominal pain

Protective Association Identified for Asthma Against Sepsis

Protective Association Identified for Asthma Against Sepsis

Decreased risk for hospital mortality, septicemia, sepsis, severe sepsis, and septic shock

is free, fast, and customized just for you!

Already a member?

Sign In Now »