Serum Trypsinogen Levels Down in Type 1 Diabetes

Share this content:
Serum Trypsinogen Levels Down in Type 1 Diabetes
Serum Trypsinogen Levels Down in Type 1 Diabetes

THURSDAY, Jan. 26, 2017 (HealthDay News) -- Patients with type 1 diabetes have significantly lower serum trypsinogen levels than those without type 1 diabetes, according to a study published online Jan. 23 in Diabetes Care.

Xia Li, M.D., from the Second Xiangya Hospital in Changsha, China, and colleagues determined serum trypsinogen levels in 100 individuals with type 1 diabetes (72 new-onset, 28 established), 99 patients with type 1 diabetes-associated autoantibodies (AAb+) with varying levels of risk for developing diabetes, 87 AAb-negative (AAb−) controls, 91 AAb− relatives with type 1 diabetes, and 18 patients with type 2 diabetes.

The researchers found that in controls, trypsinogen levels increased significantly with age; while trypsinogen levels were significantly lower in patients with new-onset and established type 1 diabetes compared with AAb− controls, AAb− relatives, AAb+ subjects, and patients with type 2 diabetes. When considering age and body mass index in multivariate analysis, trypsinogen was reduced in multiple AAb+ subjects and patients with type 1 diabetes versus AAb− subjects (controls and relatives) and single-AAb+ subjects.

"These findings further support the interplay between pancreatic endocrine and exocrine dysfunction," the authors write. "Longitudinal studies are warranted to validate trypsinogen as a predictive biomarker of type 1 diabetes progression."

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

ACOG: Shared Decision-Making Key to Breast Cancer Screening

ACOG: Shared Decision-Making Key to Breast Cancer Screening

Critically important for patient's value, preferences be factored into process, ACOG leader says

Three Lifestyle Interventions May Slow Cognitive Decline

Three Lifestyle Interventions May Slow Cognitive Decline

Cognitive training, management of hypertension, increased physical activity all help delay decline

CDC: Zika Can Be Found in Placental, Fetal Tissue at Birth

CDC: Zika Can Be Found in Placental, Fetal ...

Of 546 live births with possible maternal Zika virus, 11 percent proved positive

is free, fast, and customized just for you!

Already a member?

Sign In Now »