Macrophage COX-2 Prevents Diabetic Nephropathy Progression

Share this content:
Macrophage COX-2 Prevents Diabetic Nephropathy Progression
Macrophage COX-2 Prevents Diabetic Nephropathy Progression

WEDNESDAY, Nov. 9, 2016 (HealthDay News) -- Macrophage cyclooxygenase-2 (COX-2) deletion is associated with progression of diabetic nephropathy (DN), according to an experimental study published online Nov. 4 issue of Diabetes.

Xin Wang, from the Vanderbilt University School of Medicine in Nashville, Tenn., and colleagues examined the effects of macrophage COX-2 on development of DN in a mouse model of type 1 diabetes.

The researchers found that cultured macrophages with deletion of COX-2 exhibited a proinflammatory "M1" phenotype, with higher inducible nitric oxide synthase and NF-κB levels, but lower levels of interleukin-4Rα. Mice with COX-2 deletion in hematopoietic cells or macrophages developed severe DN compared with corresponding wild type diabetic mice, as indicated by increased albuminuria; fibrosis; and renal infiltration of T cells, neutrophils, and macrophages. Diabetic kidneys with macrophage COX-2 deletion had more infiltration of macrophages, but fewer renal "M2" macrophages (reparative phenotype); they also had increased ER stress and decreased numbers of podocytes. Results were similar in diabetic mice with macrophage E4 deletion.

"These studies have demonstrated an important but unexpected role for macrophage COX-2/PGE2/EP4 signaling to lessen progression of diabetic kidney disease, unlike the pathogenic effects of increased COX-2 expression in intrinsic renal cells," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Hospitals Vary Widely in Moving Stroke Patients to Comfort Care

Hospitals Vary Widely in Moving Stroke Patients to ...

Doctors more apt to suggest it sooner for older, white, female, and uninsured patients

Peri-Op IV Acetaminophen May Reduce Post-Op Pain in Sinus Sx

Peri-Op IV Acetaminophen May Reduce Post-Op Pain in ...

Reduction in immediate postoperative pain after endoscopic sinus surgery, but results inconclusive

Location of Body Fat Can Indicate Obesity-Related Cancer Risk

Location of Body Fat Can Indicate Obesity-Related Cancer ...

Where fat is carried is as strong a predictor as BMI, researchers suggest

is free, fast, and customized just for you!

Already a member?

Sign In Now »