H1N1 Vaccine Not Associated With Congenital Malformations

Share this content:
H1N1 Vaccine Not Associated With Congenital Malformations
H1N1 Vaccine Not Associated With Congenital Malformations

TUESDAY, Sept. 20, 2016 (HealthDay News) -- The vaccine against the H1N1 strain of influenza doesn't appear to be linked to congenital malformations, according to research published online Sept. 20 in the Annals of Internal Medicine.

Jonas Ludvigsson, M.D., Ph.D., of the Karolinska Institute in Stockholm, and colleagues looked at the risk of congenital malformations -- overall and in terms of congenital heart disease, cleft palate, and limb abnormalities -- in 40,983 children of mothers who were exposed to the H1N1 vaccine Pandemrix. The researchers compared these children to their siblings as well as to the general population.

The researchers found no sign that maternal vaccination increased the overall risk of congenital malformations in infants. The adjusted risk for congenital malformation was 4.98 and 4.96 percent in exposed and unexposed offspring, respectively (risk difference, 0.02 percent). The corresponding risk differences were 0.16 percent for vaccination during the first trimester and 0.10 percent for vaccination in the first eight weeks.

"When intrafamilial factors were taken into consideration, H1N1 vaccination during pregnancy did not seem to be linked to overall congenital malformation in offspring, although risk increases for specific malformations could not be ruled out completely," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

FDA Seeks to Increase Number of Generic Drugs on Market

FDA Seeks to Increase Number of Generic Drugs ...

Agency will now give priority reviews to new generic drugs until there are at least three available

PPIs Not Found to Raise Risk of Alzheimer's Disease

PPIs Not Found to Raise Risk of Alzheimer's ...

New research debunks other studies suggesting that PPIs cause mental decline

Aspirin Effective in Pregnancies at High Risk for Preeclampsia

Aspirin Effective in Pregnancies at High Risk for ...

Odds of preeclampsia drop for high-risk women who take 150 mg of aspirin daily, researchers find

is free, fast, and customized just for you!

Already a member?

Sign In Now »